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大黃酸

分析標(biāo)準(zhǔn)品,HPLC≥98%

Rhein

CAS號(hào)：478-43-3

分子式：C15H8O6

分子量：284.22

MDL：MFCD00009618

產(chǎn)品介紹

熔點(diǎn)：≥300℃

沸點(diǎn)：346.72℃

外觀：黃色至橙色粉末

溶解性：不溶于水，能溶于吡啶、碳酸氫鈉水溶液，微溶于乙醇、苯、氨仿、乙mi和石油醚。

儲(chǔ)存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。

參考文獻(xiàn)(76篇)

76. [IF=2.5] Wei Chen et al."Application of Chemometric Analysis With Acute Toxicity Tests of Zebrafish and Network Pharmacology for Comparison of Different Species: Rhubarb as an Example."CHEMISTRY & BIODIVERSITY.2025 Jun;:e01000

75. [IF=8.5] Xinyue Liu et al."Nitroreductase from Enterococcus faecalis catalyzes the metabolic activation of sennoside A in the colon via a unique CC reductive cleavage."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2025 Jun;:145153

74. [IF=15.8] Weikang Luo et al."Small Molecule Hydrogels Loading Small Molecule Drugs from Chinese Medicine for the Enhanced Treatment of Traumatic Brain Injury."ACS Nano.2024;XXXX(XXX):XXX-XXX

73. [IF=1.8] Jingjing Sun et al."Determination of Sennoside A in Rat Plasma by Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry and Its Application to a Rat Pharmacokinetic Study."BIOMEDICAL CHROMATOGRAPHY.2024 Nov;:e6049

72. [IF=4.4] Chenxi Wang et al."Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers."Fronti

71. [IF=6.7] Kaixin Liu et al."Polydatin mitigates thrombosis by inhibiting PHD2-induced proline hydroxylation on collagen, reducing platelet adhesion."PHYTOMEDICINE.2025 Mar;138:156392

70. [IF=5.7] Lili Yang et al."Herbal HuoXueTongFu Formula with anti-inflammatory and fibrinolytic activity regulation for the prevention of postoperative peritoneal adhesions."Frontiers in Immunology.2025 Jan;15:

69. [IF=4.7] Yijie Li et al."Anthraquinones of Cassiae Semen alleviate lipid accumulation in obesity by regulating brown adipose tissue and liver function."Chinese Herbal Medicines.2025 Feb;:

68. [IF=1.8] Shu Lianghui et al."Suyin Detoxification Prescription Regulates the Klotho and ERK/NF-κB Signaling Pathways to Alleviate Renal Injury."CELL BIOCHEMISTRY AND BIOPHYSICS.2025 Feb;:1-16

67. [IF=6.1] Jia Guo et al."Discovery of anthraquinones as potent Notum inhibitors for treating osteoporosis by integrating biochemical, phytochemical, computational, and experimental assays."Journal of Pharmaceutical Analysis.2025 Mar;:101256

66. [IF=4.8] Li He et al."Dunhuang Dabupi Decoction and its active components alleviate ulcerative colitis by activating glutathione metabolism and inhibiting JAK-STAT pathway in Drosophila and mice."JOURNAL OF ETHNOPHARMACOLOGY.2025 Apr;346:119717

65. [IF=4.7] Zhengyao Yu et al."Exploring the Therapeutic and Gut Microbiota-Modulating Effects of Qingreliangxuefang on IMQ-Induced Psoriasis."Drug Design Development and Therapy.

64. [IF=3.2] Qin Xin et al."Rhein alleviates MPTP-induced Parkinson’s disease by suppressing neuroinflammation via MAPK/IκB pathway."Frontiers in Neuroscience.2024 Jun;18:

63. [IF=1.4] Sunghanghwa Yuwathida et al."Plasmodium falciparum Lactate Dehydrogenase Inhibitory Activities of Pomegranate and Mangosteen Extracts and their Major Constituents."Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy.2024 Jul;:1-10

62. [IF=4.9] Xiaoran Zhao et al."Constructing a hydrogel based on self-assembly properties of glycyrrhizic acid: A drug delivery system with digestive tract responsive."COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS.2024 Sep;697:134497

61. [IF=4.1] Xiaoyao Liu et al."The Water Extract of Rhubarb Prevents Ischemic Stroke by Regulating Gut Bacteria and Metabolic Pathways."Metabolites".2024 Apr;14(4):216

60. [IF=4.9] Zhao Xia et al."Comparative transcriptome analysis and identification of candidate R2R3-MYB genes involved in anthraquinone biosynthesis in Rheum palmatum L.."Chinese Medicine".2024 Dec;19(1):1-18

59. [IF=4.7] Xu Zhang et al."Rhein: A potent immunomodulator empowering largemouth bass against MSRV infection."FISH & SHELLFISH IMMUNOLOGY.2024 Jan;144:109284

58. [IF=5.4] Botong Li et al."Protective effect of San Huang Pill and its bioactive compounds against ulcerative colitis in Drosophila via modulation of JAK/STAT, apoptosis, Toll, and Nrf2/Keap1 pathways."JOURNAL OF ETHNOPHARMACOLOGY.2024 Mar;322:117578

57. [IF=2.9] Qi Ying et al."Sanhuang Xiexin Decoction Ameliorates TNBC By Modulating JAK2-STAT3 and Lipid Metabolism."Chinese Journal of Integrative Medicine.2023 Nov;:1-10

56. [IF=3.4] Si Li et al."Active ingredients of Erhuang Quzhi Granules for treating non-alcoholic fatty liver disease based on the NF-κB/NLRP3 pathway."FITOTERAPIA.2023 Dec;171:105704

55. [IF=4.5] Guangtao Pan et al."Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways."Journal of Traditional and Complementary Medicine.10.1016/j.jtcme.2023.09.001

54. [IF=4.601] Yuexuan Li et al."Facile and selective separation of anthraquinones by alizarin-modified iron oxide magnetic nanoparticles."JOURNAL OF CHROMATOGRAPHY A.2023 Aug;1702:464088

53. [IF=5.195] Si Li et al."Prediction and verification of the active ingredients and potential targets of Erhuang Quzhi Granules on non-alcoholic fatty liver disease based on network pharmacology."JOURNAL OF ETHNOPHARMACOLOGY.2023 Jul;311:116435

52. [IF=9.429] Su Wenting et al."An intravitreal-injectable hydrogel depot doped borneol-decorated dual-drug-coloaded microemulsions for long-lasting retina delivery and synergistic therapy of wAMD."JOURNAL OF NANOBIOTECHNOLOGY.2023 Dec;21(1):1-19

51. [IF=6.656] Chong Chen et al."Yishen-Qingli-Huoxue Formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling."PHYTOMEDICINE.2022 Nov;:154546

50. [IF=6.78] Wanqiu Wang et al."Rhein ameliorates septic lung injury and intervenes in macrophage metabolic reprogramming in the inflammatory state by Sirtuin 1."LIFE SCIENCES.2022 Dec;310:121115

49. [IF=19.924] Liguo Jin et al."Interface Polarization Strengthened Microwave Catalysis of MoS2/FeS/Rhein for the Therapy of Bacteria-Infected Osteomyelitis."ADVANCED FUNCTIONAL MATERIALS

48. [IF=0.986] Ji-le Lan et al."Q-marker Prediction Analysis of Rhubarb in Fengyin Decoction Based on Fingerprint and Network Pharmacology:."Nat Prod Commun. 2021;16(8):

47. [IF=1.902] Ting Zhang et al."The influence of essential oils from ZhaLi NuSi Prescription on the pharmacokinetics of its non-volatile components in normal rats."Biomedical Chromatography. 2021 Oct 21

46. [IF=2.104] Jingjing Wang et al."A novel β-cyclodextrin-rhein conjugate for improving the water solubility and bioavailability of rhein."Carbohyd Res. 2020 Apr;490:107958

45. [IF=2.896] Tianming Wang et al."Quantification of prostaglandins E2 and D2 using liquid chromatography-tandem mass spectrometry in a mouse ear edema model."Anal Methods-Uk. 2020 Jun;12(22):2865-2871

44. [IF=3.361] Shen Zhuang et al."Rhein protects against barrier disruption and inhibits inflammation in intestinal epithelial cells."Int Immunopharmacol. 2019 Jun;71:321

43. [IF=3.935] Li Xie et al."Development of an UHPLC-MS/MS method for comparative pharmacokinetics of nine anthraquinones in rats and application to dosage conversion between different Semen Cassiae forms."J Pharmaceut Biomed. 2019 Sep;174:696

42. [IF=4.36] Li Lin et al."Study on the protection of water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Radix Praeparata against NAFLD and its mechanism."J Ethnopharmacol. 2020 Apr;252:112577

41. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625

40. [IF=4.759] Yueping Jiang et al."Application of multifold characteristic ion filtering combined with statistical analysis for comprehensive profiling of chemical constituents in anti-renal interstitial fibrosis I decoction by ultra-high performance liquid chromatogra

39. [IF=5.645] Li-Xia Dai et al."Ultrasound-assisted extraction of five anthraquinones from Rheum palmatum water extract residues and the antimicrobial activities."Ind Crop Prod. 2021 Apr;162:113288

38. [IF=9.381] Ya Zhao et al."Polysaccharide from vinegar baked radix bupleuri as efficient solubilizer for water-insoluble drugs of Chinese medicine."Carbohyd Polym. 2020 Feb;229:115473

37. [IF=2.406] Guo  Lei et al."Optimized extraction process and identification of antibacterial substances from Rhubarb against aquatic pathogenic Vibrio harveyi."3 Biotech. 2017 Dec;7(6):1-9

36. [IF=3.049] Yan Dai et al."Identification of drug transporters involved in the uptake and efflux of rhein in hepatocytes."Rsc Adv. 2017 Mar;7(25):15236-15245

35. [IF=3.205] Dong-Dong Hu et al."Simultaneous determination of ten compounds in rat plasma by UPLC-MS/MS: Application in the pharmacokinetic study of Ma-Zi-Ren-Wan."J Chromatogr B. 2015 Sep;1000:136

34. [IF=3.361] Yan Cheng et al."Solubility and solution thermodynamics of rhein in eight pure solvents from (288.15 to 313.15) K."Rsc Adv. 2015 Sep;5(98):80548-80552

33. [IF=3.366] Wu  Xingqiang et al."A Novel Selective Accelerated Solvent Extraction for Effective Separation and Rapid Simultaneous Determination of Six Anthraquinones in Tartary Buckwheat and Its Products by UPLC–DAD."Food Anal Method. 2015 May;8(5):1124-1132

32. [IF=3.448] Shen Zhuang et al."Rhein ameliorates lipopolysaccharide-induced intestinal barrier injury via modulation of Nrf2 and MAPKs."Life Sci. 2019 Jan;216:168

31. [IF=3.571] Shen Zhuang et al."Rhein from Rheum rhabarbarum Inhibits Hydrogen-Peroxide-Induced Oxidative Stress in Intestinal Epithelial Cells Partly through PI3K/Akt-Mediated Nrf2/HO-1 Pathways."J Agr Food Chem. 2019;67(9):2519–2529

30. [IF=3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds."Microb Pathogenesis. 2019 Jan;126:56

29.  Wang, Qian, et al. "Identification and pharmacokinetics of multiple constituents in rat plasma after oral administration of Yinchenzhufu decoction." Journal of ethnopharmacology 153.3 (2014): 714-724.https:##doi.org/10.1016/j.jep.2014.03.039

28.  Hu, Dong-Dong, et al. "Evaluation of the pharmacokinetics and renal excretion of Ma-Zi-Ren-Wan in health subjects." World Journal of Traditional Chinese Medicine 3.2 (2017): 8.DOI: 10.15806/j.issn.2311-8571.2016.0050

27.  Guo, L., Guo, J. & Xu, F. Optimized extraction process and identification of antibacterial substances from Rhubarb against aquatic pathogenic Vibrio harveyi . 3 Biotech 7, 377 (2017). https:##doi.org/10.1007/s13205-017-1012-2

26.  Shen Zhuang, Jia Zhong, Yifei Bian, Yingsai Fan, Qiyan Chen, Ping Liu, Zhongjie Liu, Rhein ameliorates lipopolysaccharide-induced intestinal barrier injury via modulation of Nrf2 and MAPKs, Life Sciences, Volume 216, 2019, Pages 168-175, ISSN 0024-3205, ht

25.  Shen Zhuang, Ruyang Yu, Jia Zhong, Ping Liu, and Zhongjie Liu,Rhein from Rheum rhabarbarum Inhibits Hydrogen-Peroxide-Induced Oxidative Stress in Intestinal Epithelial Cells Partly through PI3K/Akt-Mediated Nrf2/HO-1 Pathways,

Journal of Agricultural and F

24.  王盼,儲(chǔ)全根,軒云,蔡正銀.抵當(dāng)陷胸湯HPLC-MS指紋圖譜研究[J].時(shí)珍國(guó)醫(yī)國(guó)藥,2020,31(12):2937-2940.

23.  蘭濟(jì)樂(lè),阮葉萍,邱璐琦.基于BAS-GA-BP神經(jīng)網(wǎng)絡(luò)結(jié)合熵權(quán)法多指標(biāo)優(yōu)化風(fēng)引湯提取工藝[J].中國(guó)中藥雜志,2020,45(23):5686-5693.

22.  陸杰,王婷婷,梁琨,安叡,王新宏,陳穎.UPLC-LTQ-Orbitrap-MS法分析大承氣湯化學(xué)成分[J].中成藥,2020,42(12):3275-3280.

21.  王宇卿 李淑嬌 姜旭.HPLC-ABTS-DAD-Q-TOF/MS在線檢測(cè)大黃抗氧化活性成分[J].中國(guó)醫(yī)院藥學(xué)雜志 2019 39(11):1149-1152.

20.  李蒙蒙,田小杏,馬麗娟,蒲曉輝,袁琦,宗蘭蘭,徐穎峰.薄層色譜法鑒別三黃片中的有效成分[J].河南大學(xué)學(xué)報(bào)(醫(yī)學(xué)版),2016,35(02):81-84+109.

19.  劉全德,唐仕榮,宋慧,王營(yíng),邢洪偉.蘆薈蒽醌類(lèi)化合物的超聲提取及其抗氧化性研究[J].食品與機(jī)械,2011,27(05):68-71.

18.  郭允, 陳永超, 李曉花,等. 牛黃解毒片中6種指標(biāo)成分的含量測(cè)定[J]. 沈陽(yáng)藥科大學(xué)學(xué)報(bào), 2016(6):454-458.

17.  胡江, 繆菁, 段淑芳,等. 大黃酸對(duì)2型糖尿病模型大鼠的保護(hù)作用[J]. 中國(guó)藥房, 2014, 025(023):2113-2116.

16.  楊強(qiáng)  蒲曉輝  李曉花. 一清膠囊中7種指標(biāo)成分的測(cè)定[J]. 華西藥學(xué)雜志  2017(3).

15.  李曉花 郭允 李佳 袁琦 蒲曉輝 王高峰.RP-HPLC法同時(shí)測(cè)定三黃片中7種指標(biāo)成分的含量[J].沈陽(yáng)藥科大學(xué)學(xué)報(bào) 2016 33(08):637-642.

14.  支旭然  劉洪濤  吳茵 等. UPLC-MS/MS法同時(shí)測(cè)定腎康注射液中7個(gè)有效成分[J]. 藥物分析雜志  2017  037(001):37-42.

13.  支旭然, 白萬(wàn)軍, 王祁民,等. 腎康注射液的配伍穩(wěn)定性考察[J]. 中國(guó)藥師, 2016, 19(011):2155-2157.

12.  蔡芳, 任繁棟, 任達(dá)兵,等. 整合定性策略用于大黃素代謝物的高通量靶向鑒定[J]. 分析化學(xué), 2019, 047(008):1212-1218.

11.  張?chǎng)╂?/span>, 于孟飛, 劉貝貝,等. 大黃酸抑制氣道平滑肌收縮機(jī)制研究[J]. 江漢大學(xué)學(xué)報(bào)(自然科學(xué)版), 2019, v.47;No.160(02):62-67.

10.  段淑芳, 胡江. 大黃酸對(duì)高糖誘導(dǎo)的大鼠腎臟系膜細(xì)胞的PPARγ信號(hào)通路的調(diào)控[J]. 實(shí)用醫(yī)學(xué)雜志, 2018, 034(010):1636-1639.

9.  侍陽(yáng), 宋慶偉, 于生才,等. 大黃酸對(duì)肝移植大鼠急性排斥反應(yīng)的影響[J]. 山東醫(yī)藥, 2014, 000(046):30-32.

8.  段淑芳, 胡江, 繆菁,等. 大黃酸對(duì)糖尿病大鼠腎臟系膜細(xì)胞炎癥因子的調(diào)控[J]. 浙江中西醫(yī)結(jié)合雜志, 2016(8期):714-716.

7.  胡江, 段淑芳, 繆菁,等. 大黃酸對(duì)糖尿病大鼠合并非酒精性脂肪性肝病的保護(hù)作用研究[J]. 浙江中醫(yī)藥大學(xué)學(xué)報(bào), 2014, 38(5):521-525.

6.  段淑芳,胡江. 大黃酸對(duì)2型糖尿病大鼠胰腺的保護(hù)作用[J]. 浙江實(shí)用醫(yī)學(xué)(3期):157-159.

5.  杜睿  翁朝澤  高璐璐 等. 決明子的HPLC指紋圖譜及3種游離蒽醌含量的同步測(cè)定[J]. 藥物生物技術(shù)  2014  021(005):445-448.

4.  李宵  吳茵  支旭然 等. UPLC-MS/MS法同時(shí)測(cè)定苦黃注射液中7種成分的含量[J]. 中國(guó)藥房  2017  028(015):2108-2112.

3.  李紅英  向極釬  龍瀾 等. HPLC法測(cè)定大黃藥材中5種游離蒽醌的含量[J]. 安徽農(nóng)業(yè)科學(xué)  2013(12):5278-5279.

2.  魏艷婷  張靜宜  張華潭 等. HPLC法同時(shí)測(cè)定三黃滴丸中5種蒽醌類(lèi)成分的含量[J]. 中國(guó)藥房  2015.

1.  支旭然  董占軍  吳茵 等. HPLC同時(shí)測(cè)定腎康注射液中的4種成分[J]. 華西藥學(xué)雜志  2017(03):297-299.

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